Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors
نویسندگان
چکیده
منابع مشابه
Structural insights into the DNA-binding specificity of E2F family transcription factors
The mammalian cell cycle is controlled by the E2F family of transcription factors. Typical E2Fs bind to DNA as heterodimers with the related dimerization partner (DP) proteins, whereas the atypical E2Fs, E2F7 and E2F8 contain two DNA-binding domains (DBDs) and act as repressors. To understand the mechanism of repression, we have resolved the structure of E2F8 in complex with DNA at atomic resol...
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Sequence-specific DNA binding proteins that function as transcription factors are frequently encoded by gene families. Such proteins display highly conserved DNA binding properties, yet are expected to retain promoter selectivity. In this report we investigate this problem using the ets gene family, a group of metazoan genes whose members regulate cell growth and differentiation and are mutated...
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Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally, we discuss novel evidence that shows how these transcription factors act in a combinatorial fashion with others, through composite sites that may be crucial in det...
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ژورنال
عنوان ژورنال: Annual Review of Biochemistry
سال: 2011
ISSN: 0066-4154,1545-4509
DOI: 10.1146/annurev.biochem.79.081507.103945